Megakaryocyte contribution to bone marrow fibrosis: many arrows in the quiver
In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis.The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are Left Thumb Switch Heartrate Grip not completely understood.T